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| siroxogin | Date: Thursday, 2014-03-13, 9:54 AM | Message # 2926 |
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Group: Sveciai
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| tcsgroupw | Date: Wednesday, 2014-03-19, 4:38 PM | Message # 2927 |
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Group: Sveciai
| Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive opiate that is mainly employed after allogeneic organ move to subdue the pursuit of the unfailing's exempt set-up and so lower the danger of process rejection. It is also occupied in a topical preparation in the treatment of atopic dermatitis (eczema), strict refractory uveitis after bone marrow transplants, exacerbations of minimal transform blight, and the husk form vitiligo.
It is a 23-membered macrolide lactone discovered in 1984 from the fermentation stock of a Japanese soil test that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) forming past T-cells.
Dead letter
Tacrolimus was discovered in 1984; it was middle the first macrolide immunosuppressants discovered, preceded past the development of rapamycin (sirolimus) on Rapa Nui (Easter Islet) in 1975.[1] It is produced on a breed of soil bacterium,Streptomyces tsukubaensis.[2] The handle tacrolimus is derived from 'Tsukuba macrolide immunosuppressant'.[3]
Tacrolimus was first approved via the Edibles and Cure-all Administration (FDA) in 1994 for utilization in liver transplantation; this has been extended to include kidney, resolution, uncomfortable bowel, pancreas, lung, trachea, pellicle, cornea, bone marrow, and limb transplants.
Availability
The branded variation of the medicine is owned sooner than Astellas Pharma, and is sold under the career names Prograf given twice common,Advagraf, a unchanging releasing formulation allowing in the good old days daily dosing, and Protopic (Eczemus in Pakistan before Brookes Pharma), the topical formulation.[4] Advagraf is handy in 0.5, 1, 3 and 5 mg capsules, the ointment is concentrations of 0.1% and 0.03%.
A jiffy once-daily formulation of tacrolimus is in Phase 3 clinical trials in the U.S. and Europe. This formulation also has a smoother pharmacokinetic limn gross that reduces the peak-to-trough assortment in blood levels compared to twice-daily tacrolimus.[5] Figures from the first Time 3 contest in steady kidney transfer patients showed that this once-daily formulation was non-inferior in efficacy and shelter compared to twice-daily tacrolimus.[6] A aid Condition 3 trial in de novo patients is ongoing.[7]
Instrument of action
Tacrolimus is chemically known as a macrolide. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to turn on calcineurin. Calcineurin then dephosphorylates the transcription constituent NF-AT (nuclear aspect of activated T-cells), which moves to the pith of the T-cell and increases the labour of genes coding in behalf of IL-2 and coordinated cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.[8] In charge, Tacrolimus reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a fresh complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocytesignal transduction and IL-2 transcription.[9] Although this activity is correspond to to ciclosporin, studies secure shown that the occurrence of shrewd rejection is reduced about tacrolimus capitalize on done with ciclosporin.[10] Although short-term immunosuppression anent submissive and shoot survival is initiate to be nearly the same between the two drugs, tacrolimus results in a more favorable lipid profile, and this may have urgent long-term implications fact the prognostic affect of denial on corruption survival.[11]
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| famuyiyaoo | Date: Saturday, 2014-03-22, 4:27 AM | Message # 2928 |
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Group: Sveciai
| Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive drug that is mainly employed after allogeneic organ move to compress the pursuit of the perseverant's untouched approach and so lower the imperil of process rejection. It is also used in a topical preparation in the treatment of atopic dermatitis (eczema), severe refractory uveitis after bone marrow transplants, exacerbations of tiniest variation disease, and the crust train vitiligo.
It is a 23-membered macrolide lactone discovered in 1984 from the fermentation decoction of a Japanese filth sample that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) forming past T-cells.
Yesteryear
Tacrolimus was discovered in 1984; it was all of a add up to the opening macrolide immunosuppressants discovered, preceded near the invention of rapamycin (sirolimus) on Rapa Nui (Easter Atoll) in 1975.[1] It is produced by a archetype of stain bacterium,Streptomyces tsukubaensis.[2] The reputation tacrolimus is derived from 'Tsukuba macrolide immunosuppressant'.[3]
Tacrolimus was first approved during the Commons and Drug Superintendence (FDA) in 1994 someone is concerned use in liver transplantation; this has been extended to embrace kidney, resolution, miniature bowel, pancreas, lung, trachea, husk, cornea, bone marrow, and limb transplants.
Availability
The branded variation of the drug is owned sooner than Astellas Pharma, and is sold below the trade names Prograf given twice everyday,Advagraf, a sustained unfetter formulation allowing a single time finally daily dosing, and Protopic (Eczemus in Pakistan past Brookes Pharma), the topical formulation.[4] Advagraf is at one's fingertips in 0.5, 1, 3 and 5 mg capsules, the not bad is concentrations of 0.1% and 0.03%.
A second once-daily formulation of tacrolimus is in Aspect 3 clinical trials in the U.S. and Europe. This formulation also has a smoother pharmacokinetic vigorish that reduces the peak-to-trough rank in blood levels compared to twice-daily tacrolimus.[5] Figures from the to begin Time 3 contest in steady kidney move patients showed that this once-daily formulation was non-inferior in efficacy and shelter compared to twice-daily tacrolimus.[6] A second Condition 3 litigation in de novo patients is ongoing.[7]
Mechanism of action
Tacrolimus is chemically known as a macrolide. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to get started calcineurin. Calcineurin then dephosphorylates the transcription element NF-AT (atomic aspect of activated T-cells), which moves to the nucleus of the T-cell and increases the undertaking of genes coding benefit of IL-2 and common cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.[8] In group specifically, Tacrolimus reduces peptidyl-prolyl isomerase operation during binding to the immunophilin FKBP12 (FK506 binding protein) creating a uncharted complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin therefore inhibiting both T-lymphocytesignal transduction and IL-2 transcription.[9] Although this action is similar to ciclosporin, studies secure shown that the degree of keen also brush is reduced nearby tacrolimus utilization from ciclosporin.[10] Although short-term immunosuppression anent submissive and shoot survival is found to be comparable between the two drugs, tacrolimus results in a more favorable lipid portrait, and this may have important long-term implications fact the prognostic act upon of rejection on graft survival.[11]
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| Robertsues | Date: Saturday, 2014-03-22, 5:23 AM | Message # 2929 |
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Group: Sveciai
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| zKHIq | Date: Sunday, 2014-04-06, 11:23 AM | Message # 2930 |
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| OMzxl | Date: Sunday, 2014-04-06, 6:10 PM | Message # 2931 |
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Group: Sveciai
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| IORjdjHI | Date: Thursday, 2014-04-10, 9:18 AM | Message # 2932 |
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Group: Sveciai
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| GiannaDah | Date: Friday, 2014-04-11, 7:54 PM | Message # 2933 |
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Group: Sveciai
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| Bernarting | Date: Tuesday, 2014-04-15, 1:10 AM | Message # 2934 |
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| GiannaDah | Date: Tuesday, 2014-04-15, 4:10 AM | Message # 2935 |
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Group: Sveciai
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| IORjdjHI | Date: Tuesday, 2014-04-15, 8:31 AM | Message # 2936 |
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Group: Sveciai
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| BobbieGet | Date: Friday, 2014-04-18, 8:09 AM | Message # 2937 |
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Group: Sveciai
| If you had a chance to take the North East (Purple) MRT Line, you would’ve noticed the huge purple banners/posters featuring attractive South Asians donning beautiful jewellery.
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